On June 11, 1933, William Branham was baptizing in the Ohio River near Jeffersonville, Indiana, when a bright fiery light suddenly appeared over his head and a voice spoke out, "As John the Baptist was sent to forerun the first coming of Jesus Christ, so are you sent to forerun His second coming!" The next edition of the Jeffersonville Evening News reported the incident with the subheading, "Mysterious Star Appears Over Minister While Baptizing".

In May of 1946, he set himself aside to seek God for the meaning of his strange life. As he prayed alone late one night, an angel of light appeared, saying, "Do not fear. I am sent from the presence of Almighty God to tell you that your peculiar birth and misunderstood life has been to indicate that you are to take a gift of Divine healing to the peoples of the world. If you will be sincere when you pray and can get the people to believe you, nothing shall stand before your prayer, not even cancer. You will go into many parts of the earth and will pray for kings and rulers and potentates. You will preach to multitudes the world over and thousands will come to you for counsel." This was literally fulfilled in the years that followed, for his ministry took him around the world seven times and many individuals of public influence, including Congressman Upshaw of the U.S.A. and King George VI of England, were healed as a result of his prayers.